期刊
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
卷 182, 期 1, 页码 67-74出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotochem.2006.01.016
关键词
3-arylcoumarins; flavanocoumarins; singlet oxygen; superoxide anion
The photodynamic properties of six 3-arylcoumarins, viz., 3-phenyl-4-hydroxycoumarin (AC1), 3-phenyl-4-methoxycoumarin (AC2), 3-(4-methoxyphenyl)-4-hydroxycoumarin (AC3), 3-(4-methoxyphenyl)-4-methoxycoumarin (AC4), 3-(3',4'-methylenedioxyphenyl)-4hydroxycoumarin (AC5), 3-(3',4'-methylenedioxyphenyl)-4-methoxycoumarin (AC6) and four flavanocournarins viz., 2-(3-coumaryl)-7-methoxy3-phenylchromone (FC I), 2-(3-coumaryl)-7-methoxy-3-(4-methoxy)phenylchromone (FC II), 2-(3-coumaryl.)-5,7-dimethoxy-3-phenylchromone (FC III) and 2-(3-coumaryl)-5,7-dimethoxy-3-(4-methoxy)phenyI chromone (FC IV) are studied. The photogeneration Of O-1(2) is followed by NN-dimethyl-4-nitrosoaniline (RNO) bleaching and EPR-TEMPL (2,2,6,6-tetramethyl piperidinol) methods. Relative to rose bengal, singlet oxygen generating efficiencies of AC1, AC2, AC3, AC4, AC5 and AC6 are found to be 0.113, 0.079, 0.043, 0.028, 0.045 and 0.083, respectively. Similarly of FC 1, FC 11, FC III and FC IV are found to be 0.04, 0.03, 0. 10 and 0.06 respectively. The photogeneration Of O-2 a - is monitored by optical spectroscopy using SOD-inhibitable cytochrome c reduction assay and by EPR spin trapping method using the spin trap, 5,5-dimethyl-l-pyrroline-N-oxide (DMPO). Photogeneration Of O-2- radical is effectively enhanced by electron donors. Our results indicate that 3-arylcoumarin and flavanocoumarin derivatives possesses only moderate ability to generate O-1(2) and O-2(center dot-). Both Type I and Type 11 paths are involved in the photodynamic action of 3-arylcoumarins as well as of flavanocournarins. (c) 2006 Elsevier B.V. All rights reserved.
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