期刊
BRITISH JOURNAL OF CANCER
卷 95, 期 4, 页码 425-430出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6603274
关键词
metastasis; cancer proteomics; bioinformatics; systems biology; prostate cancer; tumour marker
类别
资金
- NCI NIH HHS [R01 CA 97063, P50 CA 69568, P30 CA046592, U01 CA 111272-01, 5P30 CA 46592, P50 CA069568, R01 CA097063] Funding Source: Medline
Molecular alterations in the prostate cancer proteome mediate the functional and phenotypic transformation from clinically localised to metastatic cancer, a transition that drives patient's mortality and challenges therapeutic intervention. A first approximation of differential proteomic alterations stratified by disease stage has yielded repertoires of potential diagnostic and prognostic markers, multiplex signatures of predictive value, and yield fundamental insight into molecular commonalities in cancer progression. Deciphering these causative proteomic alterations from the molecular noise will continue to mature our understanding of tumour biology and drive new computational and integrative approaches to model a system's view that accommodates the heterogeneity of prostate cancer progression.
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