期刊
PHYSICS IN MEDICINE AND BIOLOGY
卷 51, 期 16, 页码 3983-4001出版社
IOP PUBLISHING LTD
DOI: 10.1088/0031-9155/51/16/007
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资金
- NCI NIH HHS [R33 CA 91807] Funding Source: Medline
- NIBIB NIH HHS [R01 EB 000750-2] Funding Source: Medline
Fluorescence molecular tomography is an emerging imaging technique that resolves the bio-distribution of engineered fluorescent probes developed for in vivo reporting of specific cellular and sub-cellular targets. The method can detect fluorochromes in picomole amounts or less, imaged through entire animals, but the detection sensitivity and imaging performance drop in the presence of background, non-specific fluorescence. In this study, we carried out a theoretical and an experimental investigation on the effect of background fluorescence on the measured signal and on the tomographic reconstruction. We further examined the performance of three subtraction methods based on physical models of photon propagation, using experimental data on phantoms and small animals. We show that the data pre-processing with subtraction schemes can improve image quality and quantification when non-specific background florescence is present.
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