期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 103, 期 34, 页码 12775-12780出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0603817103
关键词
axis specification; gurken; Iintercellular communication; microtubules; oogenesis
资金
- NIGMS NIH HHS [R01 GM072562-01A2, R01 GM072562] Funding Source: Medline
Anterior-posterior axis formation in the Drosophila oocyte requires activation of the EGF receptor (EGFR) pathway in the posterior follicle cells (PFC), where it also redirects them from the default anterior to the posterior cell fate. The relationship between EGFR activity in the PFC and oocyte polarity is unclear, because no EGFR-induced changes in the PFC have been observed that subsequently affect oocyte polarity. Here, we show that an extracellular matrix receptor, Dystroglycan, is down-regulated in the PFC by EGFR signaling, and this down-regulation is necessary for proper localization of posterior polarity determinants in the oocyte. Failure to down-regulate Dystroglycan disrupts apicobasal polarity in the PFC, which includes mislocalization of the extracellular matrix component Laminin. Our data indicate that Dystroglycan links EGFR-incluced repression of the anterior follicle cell fate and anterior-posterior polarity formation in the oocyte.
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