期刊
BRAIN RESEARCH
卷 1106, 期 -, 页码 46-51出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2006.05.109
关键词
dopamine; GABA; bone marrow; progenitor cell; Parkinson's disease; transdifferentiation; transplantation
资金
- NINDS NIH HHS [R01 NS032519-14, R01 NS043309-03, NS43309, NS32519, R01 NS043309, R01 NS032519, R01 NS043309-01, R01 NS043309-02, R01 NS032519-12, R01 NS032519-13] Funding Source: Medline
Adult human bone marrow stromal cells (hMSCs) grown in suspension culture gave rise to spheres of neural progenitor (NP) cells, capable of expressing both dopaminergic (DA) and GABAergic (GABA) traits. After transplantation into the Parkinsonian rat, human NPs and neurons were present at 2 weeks. Although no DA neurons appeared to survive transplantation, there were abundant GABA neurons present in the graft. By 4 weeks, however, all cells had died. Finding ways to prolong survival and promote the appropriate neurotransmitter phenotype is essential if hMSCs are to be clinically useful. (c) 2006 Elsevier B.V. All rights reserved.
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