期刊
TETRAHEDRON
卷 62, 期 35, 页码 8262-8277出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2006.06.045
关键词
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Systematic synthesis of high-mannose-type sugar chains of asparagine-linked glycoproteins is described. To construct the target sugar chains, we employed the convergent route, using three oligosaccharide components, the common hexasaccharide, branched tri-, tetra-and pentasaccharides, and mono-, di-, and triglucosyl fragments. Construction of the beta-mannoside linkage was performed using p-methoxybenzyl-assisted intramolecular aglycon delivery. The hexasaccharide fragment was coupled with the branched mannooligosaccharide donors such as M5, M4B, WC, and M3 to give undecasaccharide (M9), decasaccharide (M8B and M8C), and nonasaccharide (M17), respectively. Incorporation of mono- di-, and triglucosyl fragments toward them gave tetradecasaccharide (G3M9), tridecasaccharide (G2M9), dodecasaccharide (G1M9), undecasaccharide (G1M8B and G1M8C), and decasaccharide (G1M7), respectively. (c) 2006 Elsevier Ltd. All rights reserved.
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