期刊
ANNALS OF EPIDEMIOLOGY
卷 21, 期 11, 页码 799-806出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.annepidem.2011.07.004
关键词
Sleep; Inflammation; Aging; Taiwan; CRP; IL-6
资金
- National Institutes of Health [R01AG016790]
- National Institute on Aging [R01AG16661]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [R24HD047879]
PURPOSE: Short and long sleep duration and sleep quality are associated with health including all-cause mortality, cardiovascular disease, diabetes, and obesity. Inflammation may play a role in mediating these associations. METHODS: We examined associations between inflammation and self-reported sleep characteristics in 1020 respondents of the 2000 and 2006 Social Environment and Biomarkers of Aging Study, a nationally representative survey of Taiwanese adults ages 53 and over. Regression models were used to estimate cross-sectional relationships between inflammation (interleukin-6, C-reactive protein, fibrinogen, e-selectin, soluble intercellular adhesion molecule-1, albumin, and white blood cell count) and a modified Pittsburgh Sleep Quality Index, index subcomponents, and self-reported sleep duration. Change in inflammatory markers between 2000 and 2006 was also used to predict long or short sleep duration in 2006. RESULTS: Inflammation was not related to the overall index of sleep quality. However, longer sleep (> 8 hr) was associated with higher levels of inflammation. These associations remained after adjustment for waist circumference, self-reported health decline, diabetes, arthritis/rheumatism, heart disease, and depressive symptoms. Increases in inflammation between 2000 and 2006 were associated with long but not short sleep duration in 2006 for several markers. CONCLUSIONS: Long sleep duration may be a marker of underlying inflammatory illness in older populations. Future studies should explore whether inflammation explains observed relationships between long sleep and mortality. Ann Epidemiol 2011;21:799-806. (C) 2011 Elsevier Inc. All rights reserved.
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