期刊
ORGANIC LETTERS
卷 8, 期 18, 页码 4105-4108出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol061619u
关键词
-
资金
- NCI NIH HHS [CA 31841] Funding Source: Medline
An efficient synthesis of the macrocyclic core of laulimalide with a pendant vinyl group at C20 is described, allowing for late-stage introduction of various side chains through a selective and efficient cross metathesis diversification step. Representative analogues reported herein are the first to contain modifications to only the side chain dihydropyran of laulimalide and des-epoxy laulimalide. This step-economical strategy enables the rapid synthesis of new analogues using alkenes as an inexpensive, abundantly available diversification feedstock.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据