期刊
ANNALS OF EPIDEMIOLOGY
卷 21, 期 9, 页码 654-659出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.annepidem.2011.04.002
关键词
Critical Period; Generalized Linear Models; Intergenerational Health; Longitudinal Study
资金
- National Health and Medical Research Council (NHMRC) [465437, 465455, 627033]
- University of Adelaide
- NHMRC Australia
PURPOSE: One of the specific aims of life course epidemiology is to assess the explanatory utility of three general hypotheses, namely he critical period hypothesis, the accumulation of risk hypothesis, and the effect modification hypothesis. METHODS: A structured regression approach to this problem is illustrated with data from an ongoing longitudinal study of children and their families established in Adelaide in 1998-2000. A series of nested models that correspond to the alternative life course hypotheses were fir in an investigation of the effects of maternal depressive stares in early childhood on internalizing child behavior at 9.5 years. Both linear and logistic regression models were considered. RESULTS: The structured regression framework showed the accumulation hypothesis was most plausible for these data. The analyses also provided some evidence of a critical period for the effect of maternal depressive status around child age 2 years on internalizing behavior at 9.5 years. CONCLUSIONS: The findings of this study suggest that comparing a suite of nested models to a full model can be useful in attempting to disentangle life course processes. Ann Epidemiol 2011;21:654-659. (C) 2011 Elsevier Inc. All rights reserved
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