期刊
ORGANIC LETTERS
卷 8, 期 18, 页码 4079-4082出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol0615782
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资金
- NIGMS NIH HHS [GM 60567] Funding Source: Medline
A second-generation synthesis of the BCDE fragment of brevetoxin A is described. Novel reactions were developed that extend the utility of the asymmetric glycolate alkylation reaction and improve scale-up to provide gram quantities of the B and E subunits. Significant improvements to the convergent assembly of the tetracycle were also realized. In addition, formation of the A ring lactone was accomplished to complete the ABCDE pentacycle.
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