期刊
VACCINE
卷 24, 期 -, 页码 26-34出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2006.05.026
关键词
HPV typing; HPV-16/18 fraction; geographical heterogeneity
Geographical widespread data on human papillomavirus (HPV) type-distribution are essential for estimating the impact of HPV-16/18 vaccines on cervical cancer and cervical screening programmes. Epidemiological studies employing a variety of HPV typing protocols have been collated in meta-analyses. HPV-16/18 is estimated to account for 70% of all cervical cancers worldwide, although the estimated HPV-16/18 fraction is slightly higher in more developed (72-77%) than in less developed (65-72%) regions. About 41-67% of high-grade squamous intraepithelial lesion (HSIL), 16-32% of low-grade squamous intraepithelial lesion (LSIL) and 6-27% of atypical squamous cells of undetermined significance (ASCUS) are also estimated to be HPV-16/18-positive, thus highlighting the increasing relative frequency of HPV-16/18 with increasing lesion severity. After HPV-16/18, the six most common HPV types are the same in all world regions, namely 3 1, 33, 35, 45, 52 and 58; these account for an additional 20% of cervical cancers worldwide. (c) 2006 Elsevier Ltd. All rights reserved.
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