An environmentally friendly synthetic method of 1,2-dihydroisoquinoline frameworks via three-component reaction with o-alkynylbenzaldehydes, primary amines, and pronucleophiles

Three-component reactions with ortho-alkynylbenzaldehydes, primary amines, and pronucleophiles (Nu-H), such as CHCl3, proceeded to give 1,2-dihydroisoquinoline derivatives in good to high yields in the absence of any catalysts under mild reaction conditions.