期刊
GUT
卷 55, 期 9, 页码 1332-1338出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/gut.2005.064774
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资金
- MRC [G106/1173] Funding Source: UKRI
- Medical Research Council [G106/1173] Funding Source: researchfish
- Medical Research Council [MC_U105260556, G0502028, G106/1173] Funding Source: Medline
Background: For patients with mild chronic hepatitis C the cost effectiveness of antiviral therapy is unknown. Aims: To assess whether antiviral therapy (either interferon alpha or peginterferon alpha combined with ribavirin) is cost effective at a mild stage compared with waiting and only treating those cases who progress to moderate disease. Patients: Cases with mild chronic hepatitis C. Methods: A cost effectiveness model which estimates long term costs and outcomes for patients with mild chronic hepatitis C. The model uses effectiveness and cost data from the UK mild hepatitis C randomised controlled trial, combined with estimates of disease progression and cost from observational studies. Results: Antiviral treatment at a mild rather than a moderate stage improved outcomes measured by quality adjusted life years (QALYS) gained. The mean cost per QALY gained from antiviral treatment with interferon alpha-2b and ribavirin, compared with no treatment at a mild stage, was 4535 pound ($7108) for patients with genotype non-1 and 25 pound 188 ($ 39 480) for patients with genotype 1. Providing peginterferon -2b pound and ribavirin at a mild rather than a moderate stage was also associated with a gain in QALYS; the costs per QALY gained were 7821 pound ($12 259) for patients with genotype non-1 and 28 pound 409 ($ 44 528) for patients with genotype 1. Conclusions: For patients with chronic hepatitis C, it is generally more cost effective to provide antiviral treatment at a mild rather than a moderate disease stage. For older patients (aged 65 years or over) with genotype 1, antiviral treatment at a mild stage is not cost effective.
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