期刊
SCHIZOPHRENIA RESEARCH
卷 86, 期 1-3, 页码 251-255出版社
ELSEVIER
DOI: 10.1016/j.schres.2006.04.004
关键词
schizophrenia; comorbidity; substance use disorder; negative symptoms; positive symptoms; PANSS
类别
As substance use disorders (SUD) are common in schizophrenia patients, we tested the hypothesis that comorbid patients (SUD [+]) have more positive vs. negative symptoms than non-comorbid (SUD[-]) patients. From reports identified by literature-searching we compared Positive and Negative Syndrome Scale (PANSS) ratings in schizophrenia patients with and without SUD using meta-analytic methods. Among 9 comparisons (N=725 subjects), SUD[+] patients were more often men, and abused alcohol > cannabis > cocaine. SUD[+] patients had very significantly higher PANSS-positive, and lower PANSS-negative scores. Comorbid SUD in schizophrenia patients was associated with male sex and higher PANSS positive to lower negative scores. Cause-effect relationships remain to be clarified. (c) 2006 Elsevier B.V. All rights reserved.
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