期刊
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
卷 91, 期 10, 页码 795-803出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/09553002.2015.1068461
关键词
Low-dose irradiation; whole-body irradiation; immune response; cytokine expression; reactive oxygen species
资金
- Nuclear Research & Development Program of the National Research Foundation of Korea [NRF-2013M2A2A7028423]
- Ministry of Trade, Industry Energy [20131610101840]
- Korea Institute of Radiological & Medical Sciences [RTR 50457-2014]
Purpose: In contrast to high-dose therapeutic irradiation, definitive research detailing the physiological effects of low-dose irradiation is limited. Notably, the immunological response elicited after low-dose irradiation remains controversial.Materials and methods: Female C57BL/6 mice were whole- body-irradiated with a single or three daily fractions up to a total dose of 0.1, 1, or 10 cGy. Blood and spleen were harvested 2, 7 and 14 days after irradiation.Results: The splenic CD4(+) T cell subpopulations were temporarily increased at 2 days after single or fractionated irradiation, whereas the percentage of dendritic cells (DC) and macrophages was decreased. Whereas CD8(+) T cell populations were decreased in single-dose irradiated mice at day 7, early and sustained reduction of CD8(+) T cell numbers was observed in fractionated- dose-irradiated mice from day 2 until day 14. In addition, single-dose irradiation resulted in a Th1 cytokine expression profile, whereas fractionated-dose irradiation drove a Th2 shift. Additionally, increased expression of immune-related factors was observed at early time-points with single-dose irradiation, in contrast to the dose-independent induction following fractionated-dose irradiation.Conclusions: Our results demonstrate that low-dose irradiation modulates the immune response in mice, where the sensitivity and kinetics of the induced response vary according to the dosing method.
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