期刊
DEVELOPMENTAL CELL
卷 11, 期 3, 页码 349-361出版社
CELL PRESS
DOI: 10.1016/j.devcel.2006.07.007
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资金
- Medical Research Council [G117/424, MC_U117527252] Funding Source: researchfish
- Medical Research Council [MC_U117527252, G117/424] Funding Source: Medline
- NHLBI NIH HHS [HL072798, HL075215] Funding Source: Medline
- MRC [G117/424, MC_U117527252] Funding Source: UKRI
Developmental studies support a common origin for blood and endothelial cells, while studies of adult angiogenic responses suggest that the hematopoietic system can be a source of endothelial cells later in life. Whether hematopoietic tissue is a source of endothelial cells during normal vascular development is unknown. Mouse embryos lacking the signaling proteins Syk and Slp-76 develop abnormal blood-lymphatic endothelial connections. Here we demonstrate that expression of GFPSlp-76 in a subset of hematopoietic cells rescues this phenotype, and that deficient cells confer focal vascular phenotypes in chimeric embryos consistent with a cell-autonomous mechanism. Endogenous Syk and Slp-76, as well as transgenic GFPSlp-76, are expressed in circulating cells previously proposed to be endothelial precursors, supporting a causal role for these cells. These studies provide genetic evidence for hematopoietic contribution to vascular development and suggest that hematopoietic tissue can provide a source of vascular endothelial progenitor cells throughout life.
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