期刊
JOURNAL OF ASTHMA
卷 43, 期 7, 页码 553-558出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/02770900600859123
关键词
asthma; obesity; spirometry; theophylline; gastroesophageal reflux disease
资金
- NCRR NIH HHS [K23 RR019965] Funding Source: Medline
Obesity is a risk factor for being diagnosed with asthma, but there is conflicting evidence on whether obesity is a risk factor for lung function abnormalities characteristic of asthma. We studied a cohort of 488 subjects, 47% of whom were obese. Obese and non-obese subjects with asthma had similar airflow limitation and bronchodilator responsiveness, but obese participants had increased sleep disturbance and gastroesophageal reflux disease, higher cytokine levels, and a trend towards increased exacerbations when treated with theophylline. Obese and non-obese asthmatics have similar lung function abnormalities, but comorbidities and altered responses to medications may significantly affect asthma control in obese people.
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