期刊
BREAST CANCER RESEARCH AND TREATMENT
卷 99, 期 2, 页码 121-134出版社
SPRINGER
DOI: 10.1007/s10549-006-9191-2
关键词
apigenin; breast cancer; estrogen receptor; genistein; phytoestrogen
类别
资金
- NCI NIH HHS [R01 CA101211, R01 CA78480] Funding Source: Medline
Genistein and apigenin are phytoestrogens present in commercial preparations used for the treatment of postmenopausal symptoms. In this study, we assessed the influence of these compounds on mammary tumor growth. Both compounds stimulate the proliferation of MCF-7 and T47D cells [estrogen receptor alpha (ER alpha-positive)], but do not stimulate the proliferation of an ER alpha-negative cell line (MDA-MB-435 cells). Genistein appeared more efficient in this regard due to its higher binding affinity for ER alpha, a property explained by a structural analysis of the binding of these compounds to the ER alpha's ligand binding domain. As previously described for estradiol (E-2), genistein and apigenin down regulated ER alpha and enhanced estrogen response element (ERE)-dependent gene expression. The additional finding that genistein antagonizes the anti-proliferative effect of hydroxytamoxifen suggests phytoestrogens may be detrimental in women with breast cancer who are being treated with tamoxifen. In addition, because of their ability to stimulate breast cell growth, the widespread use of phytoestrogens in postmenopausal women could be detrimental.
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