期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 17, 页码 4641-4643出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.05.101
关键词
acridine; antitumor; prodrugs
A series of [1,3]oxazino fused acridines has been prepared as precursors of cytotoxic 3-amino-4-bydroxymethylacridine 2. Their cytotoxic activity has been evaluated against HT29 colon carcinoma cell line and was shown to be dependent on the nature of the substituent located on position 2 of the oxazine ring. Additionally, the nitrophenyl derivative 3f is activated by nitroreductase, indicating its potency as prodrug for either gene-directed or antibody-directed enzyme prodrug therapies. (c) 2006 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据