期刊
MEMORIAS DO INSTITUTO OSWALDO CRUZ
卷 101, 期 6, 页码 693-696出版社
FUNDACO OSWALDO CRUZ
DOI: 10.1590/S0074-02762006000600020
关键词
Giardia duodenalis; protease secretion; adhesion
Protease secretion by Giardia duodenalis trophozoites upon interaction with epithelial cells and its association with the parasite adhesion was studied in co-cultures of parasites with IEC6 epithelial cell monolayers in the presence or absence of protease inhibitors. Proteolytic activity in supernatants from trophozoites was enhanced when they were co-cultured with IEC6 cells. This activity was strongly inhibited by pre-incubation of live trophozoites with E-64 and TPCK and a concomitant inhibition of parasite adhesion to IEC6 cells was observed. These data suggest that trophozoites secrete cysteine-type proteases that play a role in the adhesion of G. duodenalis to epithelial cells.
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