期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 50, 期 9, 页码 3197-3199出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00500-06
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资金
- NIAID NIH HHS [N01-AO-00042] Funding Source: Medline
- Wellcome Trust [077166/Z/05/Z] Funding Source: Medline
The anti-influenza drug oseltamivir is an ester prodrug activated by hepatic carboxylesterases. Plasma esterases also convert up to 31.8% of the parent compound to the active metabolite after 4 h ex vivo, with wide interindividual variation. This source of error is removed by adding the esterase inhibitor dichlorvos to blood collection tubes.
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