期刊
CLINICAL LYMPHOMA & MYELOMA
卷 7, 期 2, 页码 125-130出版社
CIG MEDIA GROUP, LP
DOI: 10.3816/CLM.2006.n.049
关键词
clinical guidelines; infection prophylaxis; surveillance; valganciclovir; viral reactivation
类别
The anti-CD52 monoclonal antibody alemtuzumab is highly active in the treatment of chronic lymphocytic leukemia (CLL) in patients with previously treated, relapsed, and/or refractory CLL as well as in patients with previously untreated disease. The general immunosuppressive impact and toxicities associated with alemtuzumab therapy are largely predictable and manageable. In particular, cytomegalovirus (CMV) reactivation is now a well-documented complication in patients receiving alemtuzumab. This article discusses several strategies for monitoring and treating CMV reactivation in patients with CLL receiving alemtuzumab-based therapy and provides practical recommendations for CMV management by building upon the guidelines published previously in 2004.
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