期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 17, 页码 4616-4619出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.06.004
关键词
ACE inhibitor; molecular docking; hypertension; C-domain
With a view to developing a more C-domain-selective angiotensin I-converting enzyme (ACE)-inhibitor, a novel analogue of lisinopril has been synthesized which incorporates a bulky P'(2) tryptophan functionality. This inhibitor demonstrated a significantly increased specificity for the C-domain as compared with lisinopril. Molecular docking revealed hydrophobic and hydrogen-bonding interactions with residues of the C-domain S'(2) subsite. (c) 2006 Elsevier Ltd. All rights reserved.
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