New heterocyclic hydrazones in the search for antitubercular agents:: Synthesis and in vitro evaluations

Sixteen pyrrole containing hydrazones were synthesized from isoniazid (INH) or from 1H-1-pyrrolylcarbohydrazides. Nine products exhibited 92-100% inhibitory activity against Mycobacterium tuberculosis H(37)Rv at 6.25 mu g/mL (Microplate Alamar Blue Assay). Two leads showed MICs 0.78 and > 0.1 mu g/mL, SIs > 12.82 and > 100. Drug likeness was assessed by Lipinski rule of five.