期刊
NEUROSCIENCE LETTERS
卷 404, 期 3, 页码 315-319出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2006.06.009
关键词
arryotrophic lateral sclerosis; neurofilament; ubiquitin; proteasome; immunohistochemistry
Proteasome, ubiquitin, GRAP and neurofilament were evaluated in motorneurons and astrocytes of spinal cords of ALS and control cases. ALS neurons exhibited ubiquitin positive inclusions and areas of strong immunoreaction for proteasome. Areas of proteasome stain were observed close to neurofilament positive proximal process enlargement. The percentage of neurons strongly immunoreacted, for proteasome was higher in ALS cases than in controls. Many astrocytes were positive for ubiquitin and proteasome. These results suggest that the ubiquitin-proteasome pathway is involved in the ALS pathogenesis and agree with the view that ALS is a disorder of protein aggregation that affects neurons and nonneuronal cells. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据