期刊
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
卷 6, 期 3, 页码 201-213出版社
SPRINGER
DOI: 10.3758/CABN.6.3.201
关键词
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资金
- MRC [MC_U105579219] Funding Source: UKRI
- Medical Research Council [MC_U105579219] Funding Source: researchfish
Studies of semantic impairment arising from brain disease suggest that the anterior temporal lobes are critical for semantic abilities in humans; yet activation of these regions is rarely reported in functional imaging studies of healthy controls performing semantic tasks. Here, we combined neuropsychological and PET functional imaging data to show that when healthy subjects identify concepts at a specific level, the regions activated correspond to the site of maximal atrophy in patients with relatively pure semantic impairment The stimuli were color photographs of common animals or vehicles, and the task was category verification at specific (e.g., robin), intermediate (e.g., bird), or general (e.g., animal) levels. Specific, relative to general, categorization activated the antero-lateral temporal cortices bilaterally, despite matching of these experimental conditions for difficulty. Critically, in patients with atrophy in precisely these areas, the most pronounced deficit was in the retrieval of specific semantic information.
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