期刊
EUROPEAN JOURNAL OF CELL BIOLOGY
卷 85, 期 9-10, 页码 897-904出版社
ELSEVIER GMBH
DOI: 10.1016/j.ejcb.2006.06.003
关键词
Dictyostelium discoideum; phosphoinositides; PI3K; PTEN; chemotaxis; cell migration; G proteins; G protein-coupled receptor; cAMP
类别
资金
- NIGMS NIH HHS [GM34933, GM28007, R01 GM028007] Funding Source: Medline
Chemotaxis, or cell migration guided by chemical cues, is critical for a multitude of biological processes in a diverse array of organisms. Dictyostelium discoideum amoebae rely on chemotaxis to find food and to survive starvation conditions, and we have taken advantage of this system to study the molecular regulation of this vital cell behavior. Previous work has identified phosphoinositide signaling as one mechanism which may contribute to directional sensing and actin polymerization during chemotaxis; a mechanism which is conserved in mammalian neutrophils. In this review, we will discuss recent data on genes and pathways governing directional sensing and actin polymerization, with a particular emphasis on contributions from our laboratory. (c) 2006 Elsevier GmbH. All rights reserved.
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