期刊
BONE MARROW TRANSPLANTATION
卷 38, 期 6, 页码 421-426出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bmt.1705467
关键词
cord blood transplantation; leukemia; phase II study
Cell dose is a critical determinant of outcomes in unrelated cord blood ( CB) transplantation. We investigated a strategy in which CB units should contain at least 2 x 10(7) total nucleated cells/kg of recipient weight, otherwise a second unit had to be added. We report the results of a study that was prematurely closed owing to toxicity. Patients with advanced hematologic malignancies without a human leukocyte antigen-matched sibling or unrelated donor were eligible. Conditioning regimen consisted of. udarabine and 12 Gy of total body irradiation (n = 11), or melphalan (n = 4), with antithymocyte globulin. Graft-versus-host disease prophylaxis was tacrolimus and methotrexate. Fifteen patients with acute leukemia (n = 9), chronic myelogenous leukemia (n = 2), multiple myeloma (n = 2) and lymphoma (n = 2) were treated; 60% had relapsed disease at transplantation. Three patients received double CB transplants. The 100-day and 1-year treatment-related mortality rates were 40 and 53%, respectively. Median time to neutrophil and platelet engraftment was 22 days (n = 10) and 37 days (n = 10), respectively. One patient had secondary graft failure and five patients failed to engraft. Two patients are alive and disease free; 4-year actuarial survival is 33 versus 0% for patients transplanted in remission versus in relapse. We concluded that disease status was the main determinant of treatment failure in this study.
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