期刊
CHILD CARE HEALTH AND DEVELOPMENT
卷 32, 期 5, 页码 585-589出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1365-2214.2006.00616.x
关键词
autistic spectrum disorder; melatonin; sleep problem
Background: Melatonin is often used for autistic children with sleep disorders, despite a lack of published evidence in this population. Methods: A randomized, placebo-controlled double-blind crossover trial of melatonin was undertaken in 11 children with autistic spectrum disorder (ASD). Results: Seven children completed the trial. Sleep latency was 2.6 h [95% confidence intervals (CI) 2.28-2.93] baseline, 1.91 h (95% CI 1.78-2.03) with placebo and 1.06 h (95% CI 0.98-1.13) with melatonin. Wakings per night were 0.35 (95% CI 0.18-0.53) baseline, 0.26 (95% CI 0.20-0.34) with placebo and 0.08 (95% CI 0.04-0.12) with melatonin. Total sleep duration was 8.05 h (95% CI 7.65-8.44) baseline, 8.75 h (95% CI 8.56-8.98) with placebo and 9.84 h (95% CI 9.68-9.99) with melatonin. Conclusions: Although the study was small owing to recruitment difficulties, it still provides evidence of effectiveness of melatonin in children with sleep difficulties and ASD, which we predict a larger study would confirm.
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