期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 348, 期 14, 页码 1926-1933出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200606078
关键词
alkynylation; asymmetric catalysis; camphorsulfonamides; organozinc compounds
The development of highly enantioselective catalysts involving Cu(OTf)(2) and chiral camphorsulfonamides for the alkynylation of ketone is described. The influences of Lewis acids, reaction conditions and chiral ligands on the outcome of the reaction are discussed. The best enantioselectivity (up to 97% ee) was obtained in the alkynylation of 2'-chloroacetophenone. The scope of the reaction is also examined.
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