期刊
CLINICAL BIOCHEMISTRY
卷 39, 期 9, 页码 888-892出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.clinbiochem.2006.05.006
关键词
VDR; FokI; BsmI; T1DM; complications
Background: Vitamin D receptor (VDR) mediates the effects of vitamin D. Our paper evaluates the FokI and BsmI VDR genotypes in 246 Caucasian (Italian from Lazio Region) T1DM patients compared with 246 Caucasian healthy controls, sharing age and gender and regional provenience with the patients. In addition, T1DM patients without complications were compared with those carrying three complications. Methods: Genotyping has been obtained by RFLP-PCR technique. Results: A slight significant association of T1DM with FokI homozygous f genotype was observed. No association. was observed with the presence of multiple complications by a multivariate analysis. Conclusion: T1DM patients showed slightly increased prevalence of ff VDR genotype. (c) 2006 The Canadian Society of Clinical Chemists. All rights reserved.
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