期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 101, 期 3, 页码 887-892出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00380.2006
关键词
plantar flexor muscles; lengthening contractions; sarcopenia
资金
- NIA NIH HHS [P30 AG-13283, T32 AG-00114-18] Funding Source: Medline
- NIDDK NIH HHS [T90 DK-070071] Funding Source: Medline
Effect of aging on the recovery following contraction-induced injury in muscles of female mice. J Appl Physiol 101: 887-892, 2006. First published May 18, 2006;doi:10.1152/japplphysiol.00380.2006.-By the age of 80 yr, the skeletal muscles of men and women decrease in mass and maximum force by similar to 30%. Severe contraction-induced injury may contribute to these age-related declines. One to two months after a 225 lengthening contraction protocol (LCP), muscles of young/adult male mice recovered completely, whereas those of old male mice sustained deficits of similar to 15% in mass and similar to 25% in maximum force. Although gender-related differences in the early events of contraction-induced injury have been reported, the recovery phase of muscles in old female animals has not been investigated. The hypothesis tested was that 2 mo after a severe LCP to the plantar flexor muscle group, the magnitude of recovery of mass and force for old female mice is less than that for adult female mice. The LCP was administered to muscles of adult and old, female C57BL/6 mice. At 3 days, 1 mo, and 2 mo following the LCP, maximum isometric force was measured, and muscles were removed and weighed. Two months following the LCP, the muscles of adult female mice recovered mass and force. In contrast, for old female mice, even after 2 mo, muscle masses were decreased by 11% and maximum forces by 38%. We conclude that, as reported previously for old male mice, a severe contraction-induced injury to muscles of old female mice results in prolonged deficits in mass and force.
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