期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 1, 期 3, 页码 370-383出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.200600156
关键词
antitumor agents; automated synthesis; natural products; synthetic methods; total synthesis
A 36-step synthesis was carried out in automated synthesizers to provide a synthetic key intermediate of taxol. A key step involved a microwave-assisted alkylation reaction to construct the ABC ring system from an AC precursor. Subsequent formation of the D ring afforded baccatin III, a well-known precursor of taxol.
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