期刊
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
卷 32, 期 8, 页码 981-990出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/03639040600559081
关键词
thermosoftened system; liquid-fill formulations; rheology; capsule filling; poloxamers; solid dispersion
Preliminary studies were undertaken on poloxamers to investigate their suitability for liquid-fill formulations for hard gelatin capsules. Poloxamers with viscosity in the range (0.32 - 2.8 Pa s) and melting point 48-58 degrees C were used as the continuous phase, with alpha-lactose monohydrate of negligible solubility in the molten poloxamers, as a model insoluble disperse phase. Physicochemical characterization by rheology, melt solidification and moisture uptake indicated that poloxamers were suitable excipients for liquid-filling in hard gelatin capsules. 10% w/w lactose/poloxamer dispersions were thixotropic and shear thinning and exhibited good capsule-filling properties, disperse-phase uniformity and satisfactory apparent viscosity at 70 degrees C.
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