期刊
SEMINARS IN CARDIOTHORACIC AND VASCULAR ANESTHESIA
卷 10, 期 3, 页码 228-230出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1089253206291150
关键词
fatty acid oxidation; glucose oxidation; trimetazidine
Despite the recent introduction of new therapeutic approaches to treat heart failure, mortality from heart failure remains high, and patients still frequently experience progression of contractile dysfunction and ongoing left ventricular enlargement. Therefore, new treatments are needed for heart failure that work independently of mechanisms already targeted. Emerging evidence suggests that the failure of the myocardium in heart failure is affected by alterations in the energy substrate metabolism. In particular, there is now evidence that in the failing heart, shifting metabolism away from a preference for fatty acids toward more carbohydrate oxidation can improve contractile function and slow the progression of pump failure.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据