We have studied the collective calcium signaling behavior of an array of coupled N cells, taking into account the internal noises resulting from the small cell size V. The system's performance was characterized by the reciprocal coefficient of variance (RCV) of the calcium spike train. Two system-size resonances were observed, namely, the RCV value shows a clear peak when both N and V are optimal. Therefore, an optimal number of cells of optimal size work the best as a whole.
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