期刊
NEUROPSYCHOLOGY
卷 20, 期 5, 页码 578-588出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0894-4105.20.5.578
关键词
dopamine; frontal lobe; basal-ganglia; executive function
资金
- Medical Research Council [MC_U105559847] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- MRC [MC_U105559847] Funding Source: UKRI
- Medical Research Council [G0300723B, MC_U105559847] Funding Source: researchfish
In this study, the cognitive and neurochemical factors underlying learned irrelevance, one of the mechanisms thought to be responsible for attentional set-shifting deficits in Parkinson's disease (PD), were investigated. In a visual discrimination learning task, the extent to which a target dimension was irrelevant prior to an extra-dimensional shift was varied. Twenty patients with PD and 22 healthy participants performed the task twice, with patients tested on and off L-dopa. The patients made more errors than control participants in the condition in which the target dimension was completely irrelevant prior to the extradimensional shift, but not when it was partially reinforced. Moreover, L-dopa had no effect on the patients' task performance, despite improving their working memory. These results confirm that learned irrelevance is a significant factor in accounting for attentional set-shifting deficits in patients with PD, although unlike other executive impairments in this group, the phenomenon appears to be unrelated to their central dopaminergic deficit.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据