期刊
EUROPEAN JOURNAL OF CANCER
卷 42, 期 13, 页码 2124-2135出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2006.05.015
关键词
childhood cancer; adolescent; bone neoplasms; osteosarcoma; Ewing's sarcoma; Europe; epidemiology; incidence; survival; registry
类别
Data on 5572 children and adolescents diagnosed with malignant bone tumours (international Classification of Childhood Cancer, Group VIII) before the age of 20 years during 1978-1997 in Europe were extracted from the Automated Childhood Cancer Information System (ACCIS) database. Age-standardised incidence among children during the period 1988-1997 was similar for boys and girls aged 0-14 years (5.5-5.6 per million). Among adolescents aged 15-19 years, males had higher incidence (19.3 per million) than females (10.7 per million). Among children, osteosarcoma accounted for 51% of registrations and Ewing's sarcoma for 41%. Among adolescents, 55% of registrations were osteosarcoma and 28% Ewing's sarcoma. Both tumours had their highest incidence in late childhood or early adolescence. There were no significant time trends in incidence during 1978-1997. Five-year survival estimates for patients diagnosed during 1988-1997 were, respectively, 59% and 51% among children and adolescents with osteosarcoma and 62% and 30% among children and adolescents with Ewing's sarcoma. Between 1978-1982 and 1993-1997, survival increased for both children and adolescents with osteosarcoma, and for children with Ewing's sarcoma. (c) 2006 Elsevier Ltd. All rights reserved.
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