期刊
INTERNATIONAL JOURNAL FOR PARASITOLOGY
卷 36, 期 10-11, 页码 1081-1089出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2006.06.007
关键词
transcriptome; Schistosoma; gene expression; blood fluke
类别
资金
- Wellcome Trust Funding Source: Medline
Pairing of adult Schistosoma mansoni parasites initiates a cascade of events including mating and egg production that ultimately leads to immuno-pathological lesions during schistosomiasis. To identify genes associated with this important biological process, we studied parasites isolated from single- versus mixed-sex cercariae-infected mice using DNA microarray analysis to uncover pair-regulated transcriptional profiles. We report that: (i) transcriptomes of parasites isolated from single-sex infections are significantly more complex than their mixed-sex counterparts; (ii) transcriptomes of single-sex males are distinct from mixed-sex males; and (iii) not all transcripts, previously hypothesized to be critical in female egg production, are regulated by pairing. (c) 2006 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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