期刊
JOURNAL OF MOLECULAR HISTOLOGY
卷 37, 期 5-7, 页码 219-223出版社
SPRINGER
DOI: 10.1007/s10735-006-9042-9
关键词
EZH2; breast cancer; DNA repair; homologous recombination; biomarker; prognosis; polycomb; RAD51; RAD51 paralogs; RAD51L1
类别
资金
- NCI NIH HHS [K08 CA 090876, R01 CA 107469] Funding Source: Medline
The Polycomb group protein EZH2 is a transcriptional repressor involved in controlling cellular memory and has been linked to tumorigenesis in multiple organs. In this review we summarize the current knowledge on the function of EZH2 in cancer, with special focus on breast cancer, and propose a link between EZH2, the homologous recombination pathway of DNA repair, and breast tumorigenesis.
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