期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
卷 1757, 期 9-10, 页码 1096-1109出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbabio.2006.04.015
关键词
mitochondria; cytochrome c oxidase cytochrome bcl; succinate dehydrogenase; NADH-ubiquinone oxidoreductase; electron and nuclear tunneling; oxidoreduction catalytic transformation; energy conversion
资金
- NIGMS NIH HHS [GM27309] Funding Source: Medline
The single, simple concept that natural selection adjusts distances between redox cofactors goes a long way towards encompassing natural electron transfer protein design. Distances are short or long as required to direct or insulate promiscuously tunneling single electrons. Along a chain, distances are usually 14 A or less. Shorter distances are needed to allow climbing of added energetic barriers at paired-electron catalytic centers in which substrate and the required number of cofactors form a compact cluster. When there is a short-circuit danger, distances between shorting centers are relatively long. Distances much longer than 14 angstrom will support only very slow electron tunneling, but could act as high impedance signals useful in regulation. Tunneling simulations of the respiratory complexes provide clear illustrations of this simple engineering. (c) 2006 Elsevier B.V. All rights reserved.
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