期刊
BIOLOGICAL PSYCHIATRY
卷 60, 期 5, 页码 444-453出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2006.01.011
关键词
normal aging; structural MRI; white matter; cognition; memory; executive functioning
资金
- NIA NIH HHS [AG024708-1, 5T32AG020498-02] Funding Source: Medline
- NIDA NIH HHS [5T32DA13911] Funding Source: Medline
Background. The current study utilized magnetic resonance imaging (MRI) to more fully elucidate the relationship among age, regional white matter, and neuropsychological functioning. Methods: One hundred ninety-nine neurologically healthy adults received MRI and standardized neuropsychological assessment. MR images were spatially normalized and segmented by tissue hype; relative white matter values in each of the four cerebral lobes in each hemisphere were computed. Subjects were divided into Younger (ages 21-30), Middle (ages 31-54), and Older (ages 55-79) age groups. Results: The Older group had significantly less overall relative white matter than the Middle group, who had significantly less overall relative white matter than the Younger participants (F (2, 193) = 5.42, p = 0.005). Differences in frontal lobe white matter were of largest magnitude, followed by temporal lobe (F (6, 579) = 3.32, p = 0.003). Age and frontal and temporal lobe white matter were primarily associated with performance on neuropsycbological tests of executive functioning and memory. Mediational analysis suggested that frontal lobe white matter mediated the relationship between age and performance on tasks of executive functioning and memory. Conclusions: The results confirm age-associated decline infrontal and temporal white matter, and age-related cognitive decline in several domains. Decline in neuropsychological functioning is, in part, mediated by a relative age-related reduction in frontal white matter.
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