期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 203, 期 9, 页码 2095-2107出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20060420
关键词
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资金
- FIC NIH HHS [1 R03 TW006273-01, R03 TW006273-01A1, R03 TW006273] Funding Source: Medline
- NINDS NIH HHS [R01 NS044556-01, U54 NS045309, 1R01 NS44556.01, R01 NS044556, R21 NS047298, 1 R01 NS 42893.01, R01 NS042893-01A1, U54 NS045309-01, U54 NS045309-010005, R01 NS042893, R21 NS047298-01, 1R21 NS047298-01] Funding Source: Medline
The microanatomy of immune clearance of infected brain cells remains poorly understood. Immunological synapses are essential anatomical structures that channel information exchanges between T cell-antigen-presenting cells (APC) during the priming and effector phases of T cells' function, and during natural killer-target cell interactions. The hallmark of immunological synapses established by T cells is the formation of the supramolecular activation clusters (SMACs), in which adhesion molecules such as leukocyte function-associated antigen 1 segregate to the peripheral domain of the immunological synapse (p-SMAC), which surrounds the T cell receptor-rich or central SMAC (c-SMAC). The inability so far to detect SMAC formation in vivo has cast doubts on its functional relevance. Herein, we demonstrate that the in vivo formation of SMAC at immunological synapses between effector CD8(+) T cells and target cells precedes and mediates clearance of virally infected brain astrocytes.
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