期刊
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
卷 141B, 期 6, 页码 615-622出版社
WILEY
DOI: 10.1002/ajmg.b.30344
关键词
Williams syndrome; psychopathology; children; mental retardation; intellectual disability
资金
- NICHD NIH HHS [R37 HD029957, R37 HD29957] Funding Source: Medline
- NINDS NIH HHS [R01 NS35102, R01 NS035102, R01 NS035102-13] Funding Source: Medline
The prevalence of a range of DSM-IV psychiatric disorders in a sample of 119 4-16-year-old children with Williams syndrome (WS) was assessed using a structured diagnostic interview with their parents. Most children (80.7%) met criteria for at least one DSM-IV diagnosis. The most prevalent diagnoses were Attention Deficit/Hyperactivity Disorder (ADHD; 64.7%) and Specific Phobia (53.8%). There was a significant shift in Predominant Type of ADHD as a function of CA, from Combined for the youngest group (ages 4-6 years) to Inattentive for the oldest group (ages 11-16 years). The prevalence of Generalized Anxiety Disorder (GAD) increased significantly with age. These findings are another step toward defining the behavioral phenotype of WS. (c) 2006 Wiley-Liss, Inc.
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