期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 103, 期 36, 页码 13457-13462出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0604183103
关键词
imaging; lymphoid organogenesis; transgenic mice
资金
- Medical Research Council [MC_U117573801, MC_U117512796, G0601156] Funding Source: Medline
- Medical Research Council [MC_U117512796, MC_U117573801] Funding Source: researchfish
- MRC [MC_U117573801, MC_U117512796] Funding Source: UKRI
Lymph node (LN) development depends on prenatal interactions occurring between LN inducer and LN organizer cells. We have distinguished defects in LN formation due to failure in embryonic development (aly/aly) from defects in postnatal maturation (Il2r gamma(-/-)Rag2(-/-)). Both mutant strains form normal primordial LNs with differing fate. In aly/aly mice, the LN primordium dissipates irreversibly late in gestation; in contrast, Il2r gamma(-/-)Rag2(-/-) LN anlage persists for a week after birth but disperses subsequently, a process reversible by neonatal transfer of WT IL7r(+) TCR+ T or natural killer (NK) cells, suggesting a role for IL7/IL7r interactions. Thus, we reveal a unique stage of postnatal LN development during which mature lymphocytes and IL7/IL7r interactions may play an important role.
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