期刊
DNA REPAIR
卷 5, 期 9-10, 页码 1265-1272出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2006.05.034
关键词
MLL; chromosomal translocation; infant leukemia; DNA topoisomerase II; non-homologous end joining
资金
- Intramural NIH HHS Funding Source: Medline
A wide array of recurrent, non-random chromosomal translocations are associated with hematologic malignancies; experimental models have clearly demonstrated that many of these translocations are causal events during malignant transformation. Tyanslocations involving the MLL gene are among the most common of these non-random translocations. Leukemias with MLL translocations have been the topic of intense interest because of the unusual, biphenotypic immunophenotype of these leukemias, because of the unique clinical presentation of some MLL translocations (infant leukemia and therapy-related leukemia), and because of the large number of different chromosomal loci that partner with MLL in these translocations. This review is focused on the potential mechanisms that lead to MLL translocations, and will discuss aberrant VDJ recombination, Alv.-mediated recombination, non-homologous end joining, as well as the effect of DNA topoisomerase II poisons and chromatin structure. (c) 2006 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据