期刊
REGULATORY PEPTIDES
卷 136, 期 1-3, 页码 72-77出版社
ELSEVIER
DOI: 10.1016/j.regpep.2006.04.009
关键词
relaxin-3; GPCR135 receptor; appetite; adiposity; energy expenditure
资金
- Medical Research Council [G108/535, G84/6559, G7811974] Funding Source: researchfish
- MRC [G7811974, G84/6559, G108/535] Funding Source: UKRI
- Medical Research Council [G84/6559, G7811974, G108/535] Funding Source: Medline
The effects of acute and repeated intraparaventricular (iPVN) administration of human relaxin-3 (H3) were examined on food intake, energy expenditure, and the hypothalamo-pituitary thyroid axis in male Wistar rats. An acute high dose iPVN injection of H3 significantly increased food intake I h post-administration [0.4 +/- 0.1 g (vehicle) vs 1.6 +/- 0.5 g (180 pmol H3), 2.4 +/- 0.5 g (540 pmol H3) and 2.2 +/- 0.5 g (1620 pmol H3), p < 0.05 for all doses vs vehicle]. Repeated iPVN H3 injection (180 pmol/twice a day for 7 days) significantly increased cumulative food intake in ad libitum fed animals compared with vehicle [211.8 +/- 17.1 g (vehicle) vs 261.6 +/- 6.7 g (ad libitum fed H3),p < 0.05]. Plasma leptin was increased in the H3 ad libitum fed group. Plasma thyroid stimulating hormone was significantly decreased after acute and repeated administration of H3. These data suggest H3 may play a role in long-term control of food intake. (c) 2006 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据