期刊
TETRAHEDRON LETTERS
卷 47, 期 37, 页码 6681-6684出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2006.06.176
关键词
-
Cu-I catalyzed 1,3-dipolar cycloaddition 'click chemistry' was used to prepare F-18-radiolabeled peptides. Three omega-[F-18]-fluoroalkynes were prepared in yields 1 ranging from 36% to 81%. Conjugation of omega-[F-18]fluoroalkynes to various peptides decorated with 3-azidopropionic acid via Cu-I mediated 1,3-dipolar cycloaddition yielded the desired F-18-labeled products in 10 min with yields of 54-99% and excellent radiochemical purity (81-99%). The total synthesis time was 30 min from the end of bombardment. (c) 2006 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据