期刊
JOURNAL OF CONTROLLED RELEASE
卷 114, 期 3, 页码 317-324出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2006.05.021
关键词
restenosis; rapamycin; dexamethasone; biodegradable nanoparticles
Dexamethasone- or rapamycin-loaded nanoparticles based on poly(ethylene oxide) and poly(DL-lactic-co-glycolic acid) block copolymers (PEO-PLGA) were prepared without additional stabilizer using the salting-out method. A fast release of drug in PBS (PH 7.4) at 37 degrees C resulting in 100% release within 5 It was observed for both drugs. The rate of drug release was substantially reduced by treating the particles with gelatin or albumin after drug loading, resulting in a linear drug release in time. It was shown that the rate of drug release is related to the amount of protein associated with the nanoparticles. After gelatin treatment of drug-loaded nanoparticles, sustained release of dexamethasone for 17 days and of rapamycin for 50 days could be achieved. (c) 2006 Elsevier B.V All rights reserved.
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