期刊
LIFE SCIENCES
卷 79, 期 16, 页码 1493-1506出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2006.05.007
关键词
cadmium; endothelium; VE-cadherin; angiogenesis; cancer; carcinogenesis; inflammation; testis; lung; liver; heart; kidney; cardiomyopathy; hypertension; atherosclerosis
资金
- NIAMS NIH HHS [R15 AR050985] Funding Source: Medline
- NIEHS NIH HHS [R01 ES006478] Funding Source: Medline
Cadmium (Cd) is an important industrial and environmental pollutant that can produce a wide variety of adverse effects in humans and animals. A growing volume of evidence indicates that the vascular endothelium may be one of the primary targets of Cd toxicity in vivo. Studies over the past 20 years have shown that Cd, at relatively low, sublethal concentrations, can target vascular endothelial cells at a variety of molecular levels, including cell adhesion molecules, metal ion transporters and protein kinase signaling pathways. The purpose of this review is to summarize the results of these recent studies and to discuss the implications of these findings with regard to the mechanisms of Cd toxicity in specific organs including the lung, liver, kidney, testis and heart. In addition the possible roles of the vascular endothelium in mediating the tumor promoting and anticarcinogenic effects of Cd are discussed. (c) 2006 Elsevier Inc. All rights reserved.
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